Comparison with NCBI GenBank data using BlastN or BlastX homology programs showed similarity to non-redundant gene sequences (e≤10 −10) in 868 cases (47%) and homology to human or mouse ESTs ...

The phenotype-driven dominant ENU screens proved that mutant mice are indeed indispensable for the functional analysis of the gene. In addition, the basic infrastructure required for phenotyping ...

TASTPM is a double transgenic mouse model of Alzheimer’s disease carrying two mutations associated with early onset disease: the Swedish mutation in APP and the M146V mutation in PSEN1. The double ...