Research indicates that targeting these pathways, along with key proteins like AMP-activated protein kinase (AMPK) and SIRT1, may offer new therapeutic strategies for managing conditions like ...

One study demonstrated that MA activates the AMPK/SIRT1 signaling pathway, which plays a crucial role in protecting renal function and alleviating oxidative stress and inflammation in diabetic ...

They report that it works through the lysosomal AMPK-activating pathway, which amps up AMPK in response to ... which netted 1,655 proteins that appear to associate with SIRT1. Co-immunoprecipitation ...

AMPK phosphorylates and regulates many proteins concerned with nutrient metabolism, largely acting to suppress anabolic ATP-consuming pathways while stimulating catabolic ATP-generating pathways.