Prion replication in cell lines in vitro is sensitive to antibodies directed against the normal and abnormal isoforms of the prion protein. Numerous strategies and potential targets for treating ...

A fatal disease among deer that may cause abnormal behavior including a lack of fear of humans is inching closer to the ...

Prion diseases are characterized by abnormal folding of the host’s naturally-occurring prion protein, leading to rapid neurodegeneration. They can be genetic, sporadic—without known cause—or acquired, ...

Three broad neuropathogenic mechanisms are proposed: loss of normal PrP function, abnormal PrP toxicity and ... If so, PrP C contributes to neurotoxicity in prion disease but by uncertain mechnisms.

Interestingly, the extended PMCA yielded novel forms of misfolded prions that caused new disease phenotypes. When injected into wild-type hamsters, the PMCA-generated hampster PrP Sc caused ...

Jan. 14, 2025 — Researchers have developed a gene-editing treatment for prion disease that extends lifespan by about 50 percent in a mouse model of the fatal neurodegenerative condition.

P rions are the abnormal, pathogenic agents that are transmissible and are able to induce abnormal folding of specific normal ...

The project aims to develop drugs which interacts with the biosynthetic pathway of prion protein either to stabilise its conformation or to provoke the interaction of the protein with its abnormal ...