Lysine acetylation is a significant posttranslational modification (PTM) that plays a crucial role in regulating various cellular processes across different organisms. This modification involves ...

Further candidates, including inhibitors of acetyl-lysine readers (bromodomain-containing proteins), are undergoing clinical evaluation for efficacy in different cancer settings. Among the various ...

Beyond acetylation, short-chain lysine acylations like propionylation (Kpr) and butyrylation (Kbu) link metabolism to gene regulation via acyl-coenzyme A. (acyl-CoA) availability. These ...