Symptoms of acromegaly usually begin sometime after puberty, most commonly between the ages of 40 and 50. The disease causes a person's bones to enlarge — most notably, in the hands, face and feet.

GPs who identify the clinical symptoms and signs above should refer to secondary care early for further evaluation. Acromegaly is diagnosed with elevated IGF-1 and high GH levels that are not ...

Occasionally patients with childhood or young adult onset pituitary adenomas, most often with acromegaly, carry an AIP mutation, although no known family history of pituitary adenomas is available.

If approved, paltusotine will be the first and only once-daily, oral, selective somatostatin receptor type 2 nonpeptide agonist available for adults ... of acromegaly and the symptoms related ...