Researchers at University of Tsukuba have discovered a novel mechanism involved in brain development. They found that small ...

Researchers at University of Tsukuba have discovered a novel mechanism involved in brain development. They found that small fragments called micronuclei produced by neuronal nuclei are released into ...

This adds to the growing body of work, from mouse and fly models, implicating lipid metabolism in neurodegeneration, particularly AD,” Amita Sehgal, Perelman School of Medici ...

When they read existing research on this topic, the team discovered that in early stages of the disease, microglia are not yet activated. At the early stages, they're mostly homeostatic ...

Ashvattha Therapeutics (“Ashvattha”), a clinical-stage company advancing a new class of nanomedicine therapeutics that traverse tissue barriers to selectively target and reprogram activated cells in ...

However, when exposed to nefarious stimuli, microglia transition from a resting elongated and ramified form to an activated amoeboid state, coupled with an overall enhanced pro-inflammatory phenotype.

Chronic neuroinflammation, primarily driven by activated microglia and astrocytes, is a hallmark of neurodegenerative ...

The agreement will allow Enigma to use its PET imaging tracer PMI04 to visualize microglia activity in neurodegenerative ...

“My husband and I would look at each other and say, ‘Really, both of them?’” Lazarus recalled. Mutations in NPC1 cause Niemann-Pick Type C. Mice lacking NPC1 only in microglia have rampant ...