I present the evidence that renal dysfunction is a common and powerful cardiovascular risk factor and that treatment strategies intervening in the renin–angiotensin–aldosterone system can be ...

The first recipient of a gene-edited pig kidney died from cardiac causes 52 days after xenotransplantation. The world's first ...

High blood pressure affects one in three adults, of whom a hormonal condition called primary aldosteronism accounts for one ...

Purpose: The clinical benefits, adverse effects, pharmacokinetics, and recommendations for the appropriate use of the aldosterone antagonists spironolactone and eplerenone in patients with heart ...

High blood pressure, or hypertension, affects more than 1.5 billion people worldwide and is a major cause of heart disease ...

Doctors at Queen Mary University of London, Barts Health NHS Trust, and University College London have led the development of ...

Pathophysiology of hepatorenal syndrome-acute kidney injury ... including the renin–angiotensin–aldosterone system, sympathetic nervous system, and arginine vasopressin, are activated to ...

The body retains more water and salt when kidney function declines, leading to Edema in the extremities. The hormonal axis ...

Baxdrostat is a drug that reduces aldosterone levels in the body to treat high blood pressure and other conditions. It's an ...

CEO Jon Congleton highlighted the company's focus on advancing its pivotal trials for lorundrostat, targeting dysregulated aldosterone in patients with uncontrolled and resistant hypertension. He ...