New study uncovers how antibody combinations synergistically boost complement activation to combat drug-resistant Klebsiella pneumoniae infections. In a recent Nature Communications study ...

The classical pathway of complement is activated when C1 binds to surface-bound antibody complexes. Antibody-mediated complement activation may lead to cell lysis (CDC) or lead to 'silent' ...

The complement proteins C3 and protease factor B have a central role in the activation pathways of the complement system. Recent advances in the structural biology of complement protein C3 ...

We investigated whether activation of complement early in pregnancy predicts APOs in women with systemic lupus erythematosus (SLE) and/or antiphospholipid (aPL) antibodies. Methods The PROMISSE Study ...

Antibodies and related products are the fastest ... and associated with enhanced or silenced effector functions (ADCC or complement-dependent cytotoxicity) are being investigated in clinical ...

Background: Dysregulated complement activation, increased protein citrullination ... Significantly more binding was observed in anti-citrullinated protein antibody (ACPA)-positive than in ...

"These patients also showed signs of antibody-mediated activation of the classical complement pathway, which was associated with increased anti-CMV (cytomegalovirus, also known as human herpesvirus 5) ...

Additional funding from new investor Korys, joining existing syndicate members Novo Holdings and Bioqube Ventures, brings total seed financing to €21.5mFunds will be used to further develop ...

The CAIA model of arthritis in Balb/c mice using ArthritoMab antibody cocktail (Day 0) and LPS disease booster (Day 3 ... Results: CFB is necessary for zymosan mediated activation of the alternative ...