We demonstrate here a model of accelerated and complex atherosclerosis in these diabetic apoE-null mice. Treatment of these mice with a truncated, soluble form of RAGE (sRAGE), which includes the ...

Cardiovascular disease, atherosclerosis and blood lipids; Macular degeneration ... supplements and medications on cancer prevention and treatment both in a xenograft mouse model and in vitro; Diet ...

We appreciated the FDA reviewers' alignment with our proposed clinical development program, and their positive feedback on our intended clinical trial design, IND-enabling studies, and drug ...