We demonstrate here a model of accelerated and complex atherosclerosis in these diabetic apoE-null mice. Treatment of these mice with a truncated, soluble form of RAGE (sRAGE), which includes the ...

A research team revealed that insulin-like growth factor-binding protein 6 (IGFBP6) serves as a potential therapeutic target ...

Real-time observation of certain biochemical processes in blood vessels from mice has revealed a previously unknown similarity between atherosclerosis, also known as vascular calcification ...

Cardiovascular disease, atherosclerosis and blood lipids ... supplements and medications on cancer prevention and treatment both in a xenograft mouse model and in vitro; Diet effects on antioxidant ...

Atherosclerosis risk is elevated in diabetic patients, but the underlying mechanism such as the involvement of macrophages remains unclear. Here, we investigated the underlying mechanism related to ...

We appreciated the FDA reviewers' alignment with our proposed clinical development program, and their positive feedback on our intended clinical trial design, IND-enabling studies, and drug ...