We demonstrate here a model of accelerated and complex atherosclerosis in these diabetic apoE-null mice. Treatment of these mice with a truncated, soluble form of RAGE (sRAGE), which includes the ...

Real-time observation of certain biochemical processes in blood vessels from mice has revealed a previously unknown similarity between atherosclerosis, also known as vascular calcification ...

Cardiovascular disease, atherosclerosis and blood lipids; Macular degeneration ... supplements and medications on cancer prevention and treatment both in a xenograft mouse model and in vitro; Diet ...

Atherosclerosis risk is elevated in diabetic patients, but the underlying mechanism such as the involvement of macrophages remains unclear. Here, we investigated the underlying mechanism related to ...

This model is useful for identifying and evaluating compounds to treat hypercholesterolemia or HDL/LDL-cholesterol imbalance to reduce the risk of developing atherosclerosis and a variety of other ...

We appreciated the FDA reviewers' alignment with our proposed clinical development program, and their positive feedback on our intended clinical trial design, IND-enabling studies, and drug ...