Strategies that target B cells will be discussed in the following sections, with special emphasis on agents that are either currently available or under development, and with the purpose of ...

How does LRF favour the development of B cells in the bone marrow? Treatment of Lrf-conditional-knockout mice with a potent inhibitor of Notch signalling rescued aberrant lymphoid development ...

Chronic lymphocytic leukemia (CLL) is a B-cell malignancy, with disease progression ranging from slow and indolent to ...

Lung transplant recipients are highly susceptible to infection, the researchers noted, and P. aeruginosa is a leading cause ...

institutions began using mice to isolate different cell pathways, genes, and organs to understand how the body worked and to develop therapies against disease. Today, mice are still a vital necessity ...

Researchers find that certain antioxidant enzymes, called selenoproteins, significantly contribute to fighting cell aging. The team used a gene knockout mouse model to help them study the effects of ...

This valuable study presents a mouse gastruloid model that can be used to generate hematopoietic progenitors as well as leukemic cells. However, in its current form, the manuscript is inadequate ...

But the genetically engineered rodents were unable to reproduce. Chinese researchers used embryonic stem cell engineering to ...