We are interested in mechanisms that regulate RNA Stress Granule (SG) and Processing Body (P-body) formation in cells. These two types of RNA granules aggregate translationally-silenced mRNAs and ...

Recent work has shown us that G3BP nucleation of stress granules in the absence of virus infection activates PKR, resulting in phosphorylation of eIF2alpha and activation of NF-kB and JNK signal ...

To cope with these challenges, bacteria have evolved sophisticated mechanisms known as the general stress response (GSR). This adaptive response allows them to regulate the expression of specific ...

The researchers found that the ZO-1 protein directs YB-1 to form beneficial stress granules. Stress granules are clusters of proteins that assemble inside cells exposed to stressful conditions ...

We have identified two novel chloroplast compartments with intriguingly similarities to the endoplasmic reticulum and stress granules. Another project is studying translational control in the ...