Various small RNAs of distinctive characteristics have been found and can be classified into three classes based on their biogenesis mechanism and the type of Argonaute (Ago) protein that they are ...

The biogenesis of miRNAs involves a multi-step process that begins in the nucleus and ... The pre-miRNAs are exported to the cytoplasm, where they are further cleaved by the Dicer enzyme to generate ...

Figure 1: Phenotypes of lin-4 and lin-14 mutants. Why was I so pessimistic about the prospect of lin-4 being the harbinger of a diverse class of regulatory molecules of broad importance?

Genome-wide inference of microRNA modulators identified a post-transcriptional regulatory network in GBM that was predictive of aberrant expression of GBM driver genes. MicroRNA modulators in the PCI ...

In addition, exosome delivery systems struggle with preserving bioactivity and maintaining adaptable miRNA cargoes throughout ... for efficient biogenesis of exosomes. Through the synergistic ...