The complement activation pathways converge in the proteolytic activation of C3 into C3a and C3b by the C3 convertase ... To protect their cells from the potentially damaging results of complement ...

Eosinophils and mast cells recruited by GZMK-generated pro-inflammatory C3a factor are sources of interleukin 4 (IL-4) and IL-13, both of which promote type 2 immune cell differentiation.