CCL2, a pivotal cytokine within the chemokine family, functions by binding to its receptor CCR2. The CCL2/CCR2 signaling pathway plays a crucial role in the development of fibrosis across multiple ...

In rat adjuvant-induced arthritis (AIA), CCL5 levels peak before disease onset but CCL2 levels only rise once joint inflammation is fully established. Outcomes of CCL2 or CCL5 blockade are thought ...

Here, we investigated the relative contributions of the CCL2/CCR2 versus CCL5/CCR5 chemokine axes in OA pathogenesis. Results Mice lacking CCL2 or CCR2, but not CCL5 or CCR5, were protected against OA ...

We found significant monocyte/macrophage infiltration in decidua of OAPS patients before, as well as the overexpression of CCL2, which were related to decidual inflammation. However, the detail effect ...

gmx.net Objective Monocyte chemoattractant protein-1 (MCP-1, CCL2), the primary ligand for chemokine receptor C–C chemokine receptor 2 (CCR2), is increased in livers of patients with non-alcoholic ...

1Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China. 2Department of Cell Biology, Zhejiang University School of Medicine, ...