market withdrawal due to safety concerns[^1][^2]. Moreover, the exploration of dual inhibitors that target both COX and lipoxygenase (LOX) enzymes has emerged as a promising strategy. These dual ...

The constitutive COX-1 enzyme has been considered the physiologically important isoform for PG synthesis in the normal kidney. It has, therefore, been suggested that selective COX-2 inhibitors of ...

That's because most NSAIDs, like ibuprofen, are COX-1 inhibitors, which block prostaglandins that produce inflammation. However, prostaglandins also protect your stomach lining (per the National ...