Elucidation of COX-2 regulatory pathways will lead to the development of new anti-inflammatory agents. It will be a major challenge, however, to pharmacologically modulate COX-2 function in ...

The effects of aspirin, nonspecific nonsteroidal anti-inflammatory drugs (NSAIDs), and cyclooxygenase (COX)-2 specific inhibitors on prostaglandins (PGD2, PGF2a, PGE2, PGH2) synthesis PGI ...

Although the effects of anti-inflammatory drugs have been well studied, little is known about the signaling pathways involved ... expressed COX-1 and an inducible COX-2 isoform 6.

or prostaglandin E2 (PGE2) by monocytes stimulated by bacterial lipopolysaccharide (an index of COX-2 activity). Other assays are based on measurement of collagen-or arachidonic acid-induced ...