How is a normal cell transformed into a cancerous cell? The proteins involved in cell division events no longer appropriately drive progression from one cell cycle stage to the next. Cells that ...

Tumor suppressor genes act as “brakes” to stop cells before they can travel down the road to cancer. A loss of function mutation in these genes can be disastrous. Like all genes, tumor ...

Identification of genes inactivated by promoter CpG methylation is a powerful approach to discover novel tumor suppressor candidates. PCDH10suppresses gastric cancer cell growth through cell ...

Both genes activate a signalling pathway that plays a part in the growth, division and death of cells and is therefore important for regulating the cell cycle. Previous research ... mice with ...

Short-chain fatty acids (SCFAs) like propionate and butyrate are critical byproducts of dietary fiber digestion. These ...

The body has a host of tumor suppressor genes ... provide a cushion of expendable DNA that can be lost with each rotation of the cell cycle. The trouble is that “the gene for the enzyme that maintains ...

While much has been written about the potential utility of aberrant expression of cell-cycle regulatory genes, including p53 and the retinoblastoma tumor suppressor genes, such biomarkers have not ...