这对于开发新型免疫调节疗法和抗肿瘤治疗策略具有重要意义。 图1 cGAS Nterm 调节cGAS-DNA相变聚集物的材料性质和酶活性的示意图 中国科学技术大学高大兴教授和项晟祺教授为文章的通讯作者，博士生蒋折林和石繁为本工作的第一作者。这项工作也得到了多位 ...

Efficient and site-specific genome engineering can be achieved based on programmable nucleic acid cleavage using CRISPR-Cas surveillance complexes. Structure-function studies on single component Cas ...

Zhijian “James” Chen, a biochemist at the University of Texas Southwestern Medical Center, was awarded the 2024 Albert Lasker Basic Medical Research Award for the discovery of the cGAS enzyme that ...