Efficient and site-specific genome engineering can be achieved based on programmable nucleic acid cleavage using CRISPR-Cas surveillance complexes. Structure-function studies on single component Cas ...

Human cGAS catalytic domain has an additional DNA-binding interface ... To address the challenge of how Smc5/6 translocates along DNA, we have solved the cryo-EM structure of DNA-bound 6-subunit S.

Zhijian “James” Chen, a biochemist at the University of Texas Southwestern Medical Center, was awarded the 2024 Albert Lasker Basic Medical Research Award for the discovery of the cGAS enzyme that ...