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The compounds are oral small molecules based on three distinct mechanistic platforms: calcitonin gene-related peptide (CGRP) receptor antagonists, glutamate modulators, and myeloperoxidase inhibitors.

Medically reviewed by Lindsay Cook, PharmD Ubrelvy (ubrogepant) and Nurtec (rimegepant) are prescription medications approved to help manage and offer relief for people dealing with migraine headaches ...

The Clinical Guidelines Committee of the American College of Physicians (ACP) has released a new clinical guideline on the ...

There are two types of CGRP medications: monoclonal antibodies and small-molecule antagonists (gepants ... by blocking the docking site of the CGRP receptor or the CGRP protein itself.

Over the years, the U.S. Department of Justice (DOJ) has taken a host of drugmakers to task over alleged kickback payments ...

NVI-100 is a first-in-class water-soluble peptide antagonist for the calcitonin gene-related peptide (CGRP) receptor delivered via a patient-friendly autoinjector for the acute treatment of migraine.

With historical data showing migraine to be underdiagnosed and undertreated, new guidance from the American College of ...