Regulation of complement is of critical ... Deficiencies or mutations in complement proteins may predispose individuals to infectious and immune-related diseases or may lead to excessive ...

complement is rapidly inactivated by a set of host molecules referred to as complement regulatory proteins. The new study led by Anna Ohradanova-Repic and colleagues from the Center for ...

The complement system has more than 50 soluble and membrane-bound proteins. In innate and adaptive immunity, complement is essential for eliminating foreign pathogens and apoptotic cells.

CHAPLE is associated with GI symptoms and vascular thrombosis and is caused by loss-of-function variants in the gene encoding the complement regulatory protein CD55. Recent off-label use of a ...

Other research topics include molecular characterization of complement proteins and their complexes with other proteins in regulation of neuronal synaptic loss in Alzheimer's disease, and structural ...