Prions represent a new class of infectious agents which propagate on a protein-only level, not requiring agent-encoded nucleic acids. Newly emergent prion diseases such as bovine spongiform ...

Interestingly, the extended PMCA yielded novel forms of misfolded prions that caused new disease phenotypes. When injected into wild-type hamsters, the PMCA-generated hampster PrP Sc caused ...

Researchers at the Broad Institute of MIT and Harvard have developed a gene-editing treatment for prion disease that extends lifespan by about 50% in a mouse model of the fatal neurodegenerative ...

Researchers have developed a gene-editing treatment for prion disease that extends lifespan by about 50 percent in a mouse model of the fatal neurodegenerative condition. The treatment ...