The results were temporally related to the 1) proinflammatory cytokine response (IL-1β and TNF-α) and 2) the activation of microglia/macrophages, astroglia, granulocytes, lymphocytes ...

Specifically, the toll-like receptor 4 appears to be a site at which drugs of abuse activate microglia. Toll-like receptor 4 activation consequently produces an innate immune response in the brain ...

Ncardia’s iPSC-derived microglia may aid ALS research and help to screen new therapies that target inflammation in ALS.

Ncardia, a global leader in human induced pluripotent stem cell (hiPSC) technology, today announced the launch of Ncyte® Microglia, a groundbreaking tool to advance research in neurodegenerative ...

Microglia, the primary immune cells of the ... and immune responses by releasing various cytokines. However, the ...

Image Credit: Axol Bioscience Ltd To evaluate the functional performance of the axoCells Microglia, Axol conducted various assays, such as phagocytosis, chemotaxis, and cytokine release ...

During development, there are known sex-related differences in how microglia function. But into adulthood, there was thought to be less variation in how they behave. Microglia maintain neuronal ...

Fluorescent imaging studies revealed that chronic stress activates what’s known as the NF-κB pathway, already known to regulate NLRP3 inflammasome activity, in microglia found in the mouse hippocampus ...

Stationed within the meninges, squads of immune cells lie in wait, ready to unleash an inflammatory assault within the brain if needed. Holding these trigger-happy troops back during peacetime falls ...

Cytokine and chemokine production was measured ... Specifically, astrocytes and microglia express IL-17RA in vitro, and IL-17A treatment induces biological responses in these cells, including ...

Disease-associated microglia/macrophages are thought to be ... neurodegeneration, and cytokine response (neuroinflammation).