This image depicts the chemical structure of cytosine. It shows a hexagonal ring with nitrogen atoms at positions 1 and 3, and a primary amine group attached to carbon 4. The two remaining positions ...

Six of these polymorphisms are single base pair substitutions, although one involves the simple repeat of cytosine residues at nt 311–315. The CRS has five residues in this repeat, whereas most ...

Cytosine base editors still face several limitations in practical microbial genome engineering. Here, the authors develop a high-efficiency, unbiased, wide-window, and low off-target cytosine base ...

With the arrival of a new class of single-nucleotide editors, researchers can target the most common type of pathogenic SNP in humans. Now, researchers at Harvard University have designed a new class ...

Chemical structure of guanine, showing its double-ring purine structure and the functional groups involved in hydrogen bonding with cytosine. (Image: Public Domain) Guanine has the chemical formula ...

DNA methylation is a fundamental epigenetic mechanism in which a methyl group is added onto a nucleotide, commonly cytosine. DNA methylation affects many biological processes, including gene ...

People genetically susceptible to Huntington's disease often see their movement, mood, and cognition decline slowly over time. The cause is related to expansion of repeating DNA units, in which ...

A longitudinal increase in the somatic cytosine-adenine-guanine repeat expansion ratio in blood predicted brain atrophy. Changes in cerebrospinal fluid (CSF) neurofilament light (NfL) protein and ...