Cells have a warning system to detect DNA in the cytosol, which involves activation of STING, which in turn coordinates ...

For decades, we’ve believed the bright redness of sunburn — along with its irritating sting and peeling ... and pain of sunburn may stem from damage to RNA, not DNA. “Sunburn damages the ...

(B) Acute effects of DNA damage on cell cycle progression, leading to transient arrest in the G1, S, G2, and M phases (top) and on DNA metabolism (middle). Long-term consequences of DNA injury ...

While most known types of DNA damage are fixed by our cells' in-house DNA repair mechanisms, some forms of DNA damage evade repair and can persist for many years, new research shows. This means ...

He hypothesized that DNA binds to this sensor, which then directly or indirectly activates STING. So, he focused on the chain of events upstream of STING. He obliterated STING in a murine cell line ...

Get Instant Summarized Text (Gist) DNA damage in healthy cells can persist unrepaired for years, challenging traditional views on mutation formation. This persistence allows multiple opportunities ...

Normal metabolic activity produces reactive oxygen species (ROS) that, if not eliminated, can damage cellular components. As a result, ROS from overactive mitochondria are frequently cited as a source ...

Most dividing cells in the body have well-defined checkpoint mechanisms to sense and correct DNA damage during DNA replication. Neurons, however, do not divide. For this reason, they are at ...