Studies of mismatch repair protein function will improve our understanding ... hemi-methylated GATC sites in newly replicated DNA. Activation of MutH results in single-strand scission and loading ...

A longstanding enigma in the Huntington's disease is how the mutated protein ... 6 DNA mismatch repair genes and only four of them appear to strongly (Msh3 and Pms1) or moderately (Msh2 and ...

A new UCLA Health study has discovered in mouse models that genes associated with repairing mismatched DNA are critical in ...

Defects in homologous recombination and mismatch repair ... instability can arise as a function of hypoxia-mediated resistance to apoptosis and decreased DNA repair, leading to increased rates ...