The reward for unlocking the mysteries of DNA repair could be significant ... on one of the toughest targets — the BRCA2 protein itself. It is about 10 times the size of RAD51, which makes ...

How do DNA repair mechanisms detect and repair damaged DNA, and what happens when they fail? Defects in DNA repair underlie a number of human genetic diseases that affect a wide variety of body ...

The DNA repair and replication pathways converge on a common final step in which the continuity ... Thus, the 3’-OH is important for step 2 chemistry even though it is not itself chemically ...

Homologous recombination plays essential roles in the repair of DNA double strand breaks (DSBs) and collapsed replication forks. The fundamental reaction in homologous recombination is the exchange of ...

However, the DNA damage itself is usually recognised and mended quickly by repair mechanisms in our cells. If researchers can better understand the causes and mechanisms of mutations, they may be ...

PARylation is integral to many key cellular functions, including signaling modulation and DNA repair. PARylation is reversible and is undone by PAR erasers such as poly ADP-ribose glycohydrolase (PARG ...

If these DNA breaks aren't repaired, they can prompt cells to self-destruct, or failing that, become cancerous.As LIG4 syndrome impairs this response, people with the condition are particularly ...

DNA replication is the process by which the DNA molecule makes an exact copy of itself during cell division. The double helix unwinds ... To maintain the integrity of the genetic information, cells ...

"The surprising result of our research is that DNA repair, which normally protects healthy cells, determines how cancer cells die following radiotherapy," said Prof Cesare. "The DNA inside our ...

shedding light on how DNA damage and repair occur in the brain. Their results suggest that DNA damage itself serves as the checkpoint, limiting the accumulation of genomic errors in cells during ...

which attaches itself to broken DNA strands and helps them find their way to their sibling strand, which then serves as a template to guide the repair of its twin. Another protein, RPA ...