Astrocytes are the largest and most prevalent ... a mechanism that potentially underlies cognitive deficits in Alzheimer’s disease. AstroNet, a novel data-driven algorithm, maps astrocytic ...

particularly following an insult Selective expression of mutant proteins associated with neurodegenerative diseases in astrocytes is sufficient to cause neuronal damage Mutations in the astrocyte ...

Their paper, published in Nature Neuroscience, provides one of the most detailed accounts to date of how different astrocyte subclusters respond to AD across different brain regions and disease ...

“They have done not only the screen but built the system and validated the system as well, which is really nice,” said Shane Liddelow, a neuroscientist at New York University who investigates ...

They find that individuals who carry a high burden of expanded repeats in their DNA have a more than three-fold increased risk for Alzheimer’s disease. Rabah et al. discover an astrocyte-to ...

Shane and his team set out to study the interactions between astrocytes and neurons, hoping to better comprehend the functional roles of astrocytes in a range of neurodegenerative diseases. with the ...

Understanding these functions has allowed a refocusing with regard to the role of astrocytes in neurodegenerative diseases, which has led to astrocyte-specific analyses with potential for drug ...