They find that individuals who carry a high burden of expanded repeats in their DNA have a more than three-fold increased risk for Alzheimer’s disease. Rabah et al. discover an astrocyte-to ...

particularly following an insult Selective expression of mutant proteins associated with neurodegenerative diseases in astrocytes is sufficient to cause neuronal damage Mutations in the astrocyte ...

Understanding these functions has allowed a refocusing with regard to the role of astrocytes in neurodegenerative diseases, which has led to astrocyte-specific analyses with potential for drug ...

they transitioned the astrocytes to a pathogenic state by adding microglia-derived cytokines, which are the molecular cues that induce reactivity in neurodegenerative diseases. 2 Using this system to ...

Their paper, published in Nature Neuroscience, provides one of the most detailed accounts to date of how different astrocyte subclusters respond to AD across different brain regions and disease ...

Shane and his team set out to study the interactions between astrocytes and neurons, hoping to better comprehend the functional roles of astrocytes in a range of neurodegenerative diseases. with the ...