because they do not cause behavioral signs associated with activation of either normosensitive or supersensitive postsynaptic dopamine D 2 receptors (e.g., increased locomotion in reserpinized ...

The interested hits were evaluated for their activities against various dopamine receptors. Fourteen hits were identified from primary screening, of which 2 of the better hit samples, HD0522 and ...

In a study by Gare et al. [7] a total of 66 patients with chronic renal failure and/or diabetes mellitus received low-dose dopamine (2 µg/kg/min) plus saline or saline alone for 48 hours.

DOI: 10.1038/s41593-024-01819-9 Nicolas X. Tritsch, Motivating interest in D3 dopamine receptors, Nature Neuroscience (2024). DOI: 10.1038/s41593-024-01820-2 ...

Recently, timed-release bromocriptine (Cycloset), a sympatholytic dopamine D 2 receptor agonist, has been approved by the U.S. Food and Drug Administration (FDA) for the treatment of type 2 diabetes.

Increasing calcium restored dopamine release, showing that the problem lies in nicotinic receptor function. "Our findings suggest that behavioral inflexibility in autism arises from deficits in ...