The second tool is the CRISPR-Cas9 system, which allows easy and precise editing of any region of the genome. When it comes to traditional immortalized cell lines, such as HeLa or HEK293, cutting with ...

This is the first report of the chemoprotective efficacy of a relatively new thiol antioxidant, N-acetylcysteine amide (NACA), on DOX-induced cell death in cardiomyocytes. We hypothesized that ...

With the recent establishment of the CRISPR/Cas-based chromosome engineering technique, pre-defined chromosome rearrangements can now be induced, and their genetic and epigenetic consequences can ...

To determine a sublethal concentration of NACA for the study on its ability to protect H9c2 cells from DOX-induced toxicity, we first exposed cells with NACA at 0.25 mM, 0.50 mM, 0.75 mM ...