16). We tested the hypothesis that mutant APP causes age-dependent learning impairment through disruption of synaptic plasticity. Figure 2: LTP is impaired in the dentate gyrus in aged APP 695 SWE ...

Synaptic plasticity is the biological process by which specific patterns of synaptic activity result in changes in synaptic strength and is thought to contribute to learning and memory.

The Brain Prize recognizes the three scientists’ research on the molecular mechanisms behind neural plasticity: the brain’s ability to rewire connections as it learns, develops, heals from injury, and ...