And these then often change how fast the substrate gets in, or how fast the product goes out again, speeding up the rate of the binding step of the reaction. Yes, so OGG1 is a DNA repair enzyme ...

I was a young enzymologist looking for a new project, and immediately volunteered for this one, which involved a peptidase of apparently unique mechanism and an enzyme product of potentially great ...

(Image: National Human Genome Research Institute) Enzymes are highly specific to their substrates, the molecules upon which they act. The active site of an enzyme has a unique three-dimensional ...

Functional assays showed that the enzyme dimer self-regulates through a mechanism called negative cooperativity. In this process, when a substrate binds to one-half (protomer) of the dimer ...

Inhibitors can be used to stop an enzyme from binding to its substrate. As a result, inhibitors can directly control the progress of a metabolic pathway.

activity assays determined that GnT-IVa enzyme with GlcNAc glycan branches (higher binding) near the lectin domain decreases the activity of modified GnT-IVa toward glycoprotein substrates.

Here we explore peptide inhibitors of Cdc20, a substrate-recognition subunit and activator of the E3 ubiquitin ligase the anaphase promoting complex/cyclosome (APC/C) that is essential in mitosis and ...

E1 enzymes facilitate conjugation of ubiquitin and ubiquitin-like proteins through ... Reconstituting SUMO conjugation in vitro revealed distinct motifs in the E2 required for substrate binding and ...

Yulan Xiong, associate professor of neuroscience at UConn Health, and her team have discovered one more piece of the puzzle ...