A number of spontaneous mutations in GFAP, encoding an astrocyte-specific intermediate filament protein, causes a neurodegenerative disease. It seems probable that these mutations effect gain of ...

This dissertation focuses on the glial protein GFAP and Alexander disease, a severe neurological disorder primarily affecting young children. Mutations in the GFAP gene disrupt astrocyte function, ...

Cells were immunostained for type III ß-tubulin (immature neurons, green), GFAP (astrocytes, red) and NG2 (immature oligodendrocytes, blue). Scale bar, 50 µm Precursor cells from irradiated ...

New research found significant changes in brain biomarkers linked to Alzheimer's disease in those who had contracted the ...

B. Blockade effect of Mct1 gene-silencing on 14C-acetate uptake in primary cultured astrocytes. C. Representative images displaying GFAP and MCT1 expressions in primary cultured astrocytes 48 ...

Transgenic and knockout mice have been valuable in helping us to understand the pathophysiology of neurodegenerative disorders. Transgenic models for specific neurodegenerative disorders including ...

And GFAP, a marker of astrocyte activation and neuroinflammation, was also higher in those who had Covid. These changes were comparable to four years of ageing or 60% of the effect size of ...