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Ferroptosis and intrinsic drug-induced liver injury by acetaminophen and other drugs: a critical evaluation and historical perspective
The discovery of ferroptosis—a regulated form of cell death characterized by glutathione depletion, inactivation of glutathione peroxidase 4 (GPx4), and iron-dependent propagation of LPO—has ...
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铁死亡的“天敌”：GPX4棕榈酰化调节机制的创新发现
【导读】S-棕榈酰化是一种可逆的、广泛存在的翻译后修饰，但人们对其在调控铁变态反应中的作用却知之甚少。在这项研究中，团队阐明了铁变态反应的重要调节因子GPX4在半胱氨酸66上可逆地发生棕榈酰化。2025年1月20日， 深圳湾实验室尹成骞教授团队在期刊 ...
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Study reveals ferroptosis as a major driver of severe COVID-19 lung damage
Lipid peroxidation adversely impacts the cellular repair system, particularly the ferroptosis suppressor protein 1 (FSP1), glutathione peroxidase 4 (GPX4) pathway, and GTP cyclohydrolase 1 (GCH1 ...
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Targeting ferroptosis for overcoming chemoresistance in digestive tract tumors
Various molecular pathways, such as glutathione peroxidase 4 (GPX4) inhibition, iron metabolism deregulation, and polyunsaturated fatty acid metabolism, converge to regulate ferroptosis.