Polymorphisms in the CYP3A gene or other genetic loci controlling expression and function of CYP3A4 may explain the person-to-person variations seen in intensity and duration of drug action ...

In one particular area of study, variations in DNA sequences (i.e., genetic polymorphisms) explain some of the variability in drug-metabolizing enzyme activities which contribute to alterations in ...

has demonstrated that polymorphic metabolism has a genetic basis. Four of the eight or so major human P450s, which together metabolize about 40–50% of drugs, exhibit genetic polymorphism ...

Pharmacogenetics has elucidated the genetic basis for interindividual variability in drug response. Pharmacogenetics will continue to play a key role in defining strategies to optimize drug therapy.