You have full access to this article via your institution. Figure 1: A family with multiple GISTs and mutation of the KIT gene.

近期，宁夏医科大学基础医学院的 Liangying Zhang、Kun Xiao 等研究人员在《Scientific Reports》期刊上发表了题为 “SOCS2 inhibits the tumorigenesis of GISTs and increases the sensitivity of GISTs to imatinib by suppression of KIT ...

designed to address both primary and secondary KIT mutations in patients with GIST. Early data from the StrateGIST 1 Phase I/Ib trial demonstrated promising antitumor activity, with an objective ...

The tyrosine kinase inhibitor imatinib targets the human KIT receptor and the platelet-derived growth factor receptor-α. This drug exhibits impressive antitumor effects against GIST and has ...

IDRX-42 has demonstrated activity against all key primary and secondary KIT mutations, designed to improve outcomes for patients with GIST. Updated clinical data from StrateGIST 1, an ongoing ...

GIST usually occurs in the GI tract, with 80 percent of cases caused by mutations in the KIT gene. The mutations promote the growth and survival of tumor cells. After first-line treatment ...

The first 2 criteria are associated with imatinib's efficacy in CML (BCR-ABL fusion), GIST (KIT or PDGFRA mutation), and HES (FIP1L1-PDGFRA fusion). The information we have for SCLC in regard to ...

GIST typically presents in the GI tract with 80% of cases driven by mutations in the KIT gene that lead to the growth, proliferation, and survival of tumour cells (primary or activating mutations).

IDRX-42 is a selective tyrosine kinase inhibitor (TKI) designed to treat gastrointestinal stromal tumours (GIST) by targeting all major KIT mutations, which are critical drivers of the disease.

"IDRX-42 has demonstrated activity against all key primary and secondary KIT mutations, designed to improve outcomes for patients with GIST," according to a joint statement. "This breadth of ...

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