Glycolysis is a central metabolic pathway by which cells obtain energy from sugar. Cancer cells in particular have long been thought to depend on the energy obtained through glycolysis, a phenomenon ...

However, when the researchers blocked an “earlier” step in glycolysis, the enzyme glucose-6-phosphate isomerase, this had no effect on the growth of the cancer cells. “The glycolytic enzyme ...

This makes the results published by Almut Schulze and colleagues from the German Cancer Research Center (DKFZ) all the more surprising: when the researchers blocked the enzyme aldolase A, which ...