High-grade prostatic intraepithelial neoplasia (HGPIN) is the most likely precursor of prostatic adenocarcinoma according to virtually all available evidence. This lesion is characterized by ...

Other findings in the prostate might also indicate premalignant disorders, such as low-grade PIN ... can be demonstrated by immunostaining for high-molecular-weight cytokeratins (34βE12) or ...

Proliferative inflammatory atrophy is often identified adjacent to high-grade prostatic intraepithelial neoplasia. With respect to molecular pathways, proliferative inflammatory atrophy ...

Cancer Res 63: 6237-6243. Freeman K, Welm B, Gangula R, Rosen J, Ittmann M, Greenberg N and Spencer D. 2003. Inducible prostate intraepithelial neoplasia with reversible hyperplasia in conditional ...