Human artificial chromosomes (HACs ... However, challenges such as the limited retention of the HAC vector and the production of the dystrophin protein need to be addressed for long-term efficacy.

To convert a piece of cloned DNA into a centromere-containing human artificial chromosome (HAC), an array of repeated LacO sequences is incorporated into the DNA. The DNA is then transfected into ...

Nakano et al. now describe a novel human artificial chromosome (HAC) that allows for the first time the manipulation of the epigenetic state of chromatin within an active kinetochore. They show ...

Kuroiwa et al. prepared a human artificial chromosome (HAC) vector containing the entire unrearranged sequences of the human immunoglobulin (hIg) heavy-chain (H) and lambda (λ) light-chain loci. They ...

Researchers have been able to get small artificial human chromosomes to form from self-linking lengths of DNA added to cells, ...

Logsdon and others recently published another study last week in Science, which showed that enlarging the artificial ...