Overall, 582 individuals were diagnosed with AD. Use of either lipophilic statins (simvastatin, atorvastatin or cerivastatin) or hydrophilic statins (pravastatin, fluvastatin or rosuvastatin ...

If statin-associated cognitive impairment is suspected, a trial discontinuation can reveal a temporal relationship. Switching from lipophilic to hydrophilic statins may resolve cognitive impairment.

Statins are categorized as either lipophilic, dissolving in fats, or hydrophilic, dissolving in water. This distinction matters because some studies have linked lipophilic statins to brain-related ...

In rare cases, statins could also cause severe muscle damage called "rhabdomyolysis." "Pravastatin might have a slightly lower risk of side effects since it's hydrophilic (water-soluble), which ...