Hyper-IgE syndrome (HIES ... research has also focused on the role of STAT3 mutations in HIES. These mutations typically lead to a deficiency in Th17 lymphocytes, which are crucial for immune ...

The hyper IgE ... serum IgE, rash, and recurrent bacterial infections of the skin and lung. Autosomal dominant HIES, the most common disease in this group, results from STAT3 mutations and has ...