NLRP1 inflammasome activity is regulated by the anti-apoptotic mitochondrial factors BCL-2 (B-cell lymphoma 2) and BCL-X L. NAIP5 (neuronal apoptosis inhibitory protein 5) mediates cell death in ...

The NLRP3 complex, whose gene Ran referred to, is the notorious cell-death inflammasome, which can trigger proinflammatory activity via multiple types of stimuli. NLRP3 apparently becomes ...

Acute respiratory distress syndrome (ARDS) is present in >10% of all people admitted to critical care and is associated with severe morbidity and mortality. Despite more than half a century since its ...

Genetically disrupting inflammasome activity in the Eµ-myc mice greatly accelerated stem cell proliferation and tumor development. The investigators were surprised to find that stem cells in ...

Get Instant Summarized Text (Gist) The inflammasome, a group of immune proteins, can prevent blood stem cells from becoming cancerous by removing specific receptors and inhibiting cancer gene activity ...

The findings bolster the idea that the inflammasome has a dual role—it promotes inflammation associated with poor outcomes in late cancer stages, but early on, it can help prevent cells from ...

The Bachovchin lab uses chemical and cell biology approaches to study important questions in innate immunity. We are particularly interested in characterizing the molecular mechanisms controlling the ...

and reactive oxygen species accumulate in the eye and trigger inflammasome activation as a final common pathway, which then causes cells in the macula to slowly die (atrophy). Over time ...

Aligning therapies with the biologic clock may improve efficacy, as macrophage activity peaks early in the morning, worsening inflammatory disease symptoms.