NLRP1 inflammasome activity is regulated by the anti-apoptotic mitochondrial factors BCL-2 (B-cell lymphoma 2) and BCL-X L. NAIP5 (neuronal apoptosis inhibitory protein 5) mediates cell death in ...

The NLRP3 complex, whose gene Ran referred to, is the notorious cell-death inflammasome, which can trigger proinflammatory activity via multiple types of stimuli. NLRP3 apparently becomes ...

Acute respiratory distress syndrome (ARDS) is present in >10% of all people admitted to critical care and is associated with severe morbidity and mortality. Despite more than half a century since its ...

A group of immune proteins called the inflammasome can help prevent blood stem cells from becoming malignant by removing certain receptors from their surfaces and blocking cancer gene activity ...

Microplastics pose a threat to heart health, causing harmful changes in vascular cells and increasing the risk of cardiovascular diseases like atherosclerosis.

The findings bolster the idea that the inflammasome has a dual role—it promotes inflammation associated with poor outcomes in late cancer stages, but early on, it can help prevent cells from ...

Get Instant Summarized Text (Gist) The inflammasome, a group of immune proteins, can prevent blood stem cells from becoming cancerous by removing specific receptors and inhibiting cancer gene activity ...

The Bachovchin lab uses chemical and cell biology approaches to study important questions in innate immunity. We are particularly interested in characterizing the molecular mechanisms controlling the ...

and reactive oxygen species accumulate in the eye and trigger inflammasome activation as a final common pathway, which then causes cells in the macula to slowly die (atrophy). Over time ...