On the basis of these facts, I speculated that a cholesterol-synthesis inhibitor, particularly a HMG-CoA reductase inhibitor, would be an effective cholesterol-lowering agent. In the 1960s ...

HMG-CoA reductase inhibitors, commonly referred to as statins, are the cornerstone of pharmacologic reduction of elevated low-density lipoprotein cholesterol. LDL-C is the main contributor to ...

In patients with hypercholesterolemia, ezetimibe added to ongoing HMG-CoA reductase inhibitor therapy significantly lowered total cholesterol, LDL-C, apolipoprotein B, and triglycerides and ...

They work by inhibiting an enzyme in the liver called HMG-CoA reductase and by inhibiting ... that same effect of causing liver damage. PCSK9 inhibitors are a new class of medications that may ...

Standard treatment with/without the potent HMG-CoA reductase inhibitor pravastatin, was compared with death as the primary endpoint. All patients underwent TAE followed by oral 5-FU 200 mg/day for ...

aldosterone antagonists and HMG-CoA reductase inhibitors. Early antithrombotic administration at the time of STEMI diagnosis consists of non-enteric-coated aspirin 162 mg to 325 mg (unless ...

Concomitant cisapride, pimozide, ergots, lomitapide, HMG-CoA reductase inhibitors extensively metabolized by CYP3A4 (lovastatin or simvastatin). Concomitant colchicine (in renal or hepatic ...