Isotretinoin is indicated for nodular acne or severe acne that is unresponsive to conventional therapies. The usual dose is 0.5 to 1.0 mg/kg/day for 20 weeks, or a cumulative dose of 120 mg/kg.

Expert Rev Clin Pharmacol. 2010;13(4):563-580. Currently, isotretinoin is only licensed for the treatment of severe acne. However, in recent years, dermatologists have expanded their indications ...

Isotretinoin, commonly called Accutane, is the only approved treatment for severe acne. Although isotretinoin is extremely effective in most individuals with acne, some experience recurrence.

Higher cumulative doses of isotretinoin showed a decreased risk for acne relapse. These findings suggest an individualized approach to care should be implemented. The risk for acne relapse ...

Isotretinoin, commonly referred to as Accutane, is the only approved medical treatment capable of inducing long-term remission of severe acne. Although highly effective, some individuals ...

Combination birth control pills can help treat existing acne and reduce the severity ... term medications like the pill or spironolactone. Isotretinoin (Accutane) may be prescribed in severe ...

found that 22.5 percent had acne relapse and 8.2 percent had isotretinoin retrial. Cumulative dosage was significantly associated with decreased rates of relapse and retrial (hazard ratio [HR], 0. ...