Three different hTERT-immortalized human primary renal proximal tubule epithelial cells (RPTEC) were modified and tested for functionality and stable expression of the OAT1, OCT2, and OAT3 proteins.

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The work included in vitro renal transporter studies using Newcells' aProximate TM model, comparing proximal tubule cell flux in rats, dogs, and humans. The data was analyzed to provide a ...

Each kidney contains over one million microscopic filtering units called nephrons. Each nephron is made of a tubule and is responsible for 'cleaning' the blood by removing urea and excess water ...