“I believe we've hit not only the cell of origin for lung adenocarcinoma, but also the pathway of origin,” says Kadara. This cancer originates in the epithelial cells that line the lung’s ...

Lung cancer remains the leading cause of cancer-related deaths globally, with cigarette smoking as its primary driver.

Human lung epithelial cell line A549 (derived from human pulmonary adenocarcinoma) and human embryonic kidney epithelial cell line HEK293 were obtained from American Type Culture Collection (ATCC, ...

Objective Here we aimed to develop an organoid model representative of human distal lung tissue comprised of primary human pulmonary epithelial, mesenchymal and endothelial cells. Methods Primary ...

Notably, the activation of cGAS-STING is not canonical in this case since a restriction of IRF3 nuclear transcription and subsequent IFN I induction was reported from the transcriptomic profiles, and ...

Alveolar cells, which are epithelial cells crucial for gas exchange inside the lung, can be grouped into two cell types. Type I cells are more common and primarily function in gas exchange ...

An imbalance in gene activity in two types of immune cells explains why lung fibrosis after a severe COVID-19 infection doesn ...

In idiopathic pulmonary fibrosis (IPF) patients, alveolar epithelium architectures are persistently lost and lung gas transfer function would decline over time, which cannot be rescued by conventional ...

Lung cancer expert Triparna Sen delivered a seminar in the Cancer Biology Seminar Series at the University of Wisconsin Jan.

Background Idiopathic pulmonary fibrosis (IPF) is characterised by scarring of lung interstitium and destruction of epithelial basement membrane. Cell extrusion maintains tissue architecture, whilst ...

After the lung adenocarcinoma tissue sample was taken ... A state consisting of cells mainly derived from nonmalignant tissues in a cluster identified as epithelial cells was defined as “root cells.” ...